If you have a domain network, I believe it is possible to deploy the registry settings through a GPO, and for the Task List a startup script may work. I do recognise that enterprise deployments are a little sticky at the moment, but I don't really know what would be needed for larger deployments (e.g. like yours) as my network only has about 10 computers (it's a personal one, not a corporate one, but with AD and all)